ID you entered:  ENSP00000302269

Ensembl protein: ENSP00000302269   

          Protein sequence 
Name: VAV1
Description: vav 1 guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:12657]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0396751, hypergeometric test )
                 59 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.0000787531, hypergeometric test )
                 30 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs9138E59K1PF00307  PF11971  Lung Cancer18948947   Ding2008, COSMICSYK, EGFR, TEC, JAK2
    2cs86807A264T0PF00621  Skin Cancer21984974   COSMICPIK3R1, RAC1, TEC, PLCG1,
    3cs7177R276K2PF00621  Melanoma COSMICPIK3R1, RAC1, TEC, PLCG1,
    4cs92242D394G-1Ovarian Cancer21720365   COSMIC
    5cs93733K435N0PF00169  Ovarian Cancer21720365   COSMICRAC1, TEC, PLCG1, GRB2, S
    6cs62236S459L-2PF00169  Breast Cancer20668451   COSMICRAC1, TEC, PLCG1, GRB2, S
    7cs79467Y482H2PF00169  Ovarian Cancer21720365   COSMICRAC1, TEC, PLCG1, GRB2, S
    8cs66026D517E2PF00130  Lung Cancer20668451   COSMICPIK3R1, SYK, TEC, PLCG1,
    9cs59346R618W-3PF07653  PF00018  Head and Neck Cancer21798893   COSMICSH3BP2, SYK, TEC, EGFR, P
    10cs7176E626K1PF07653  PF00018  Renal Cancer20054297   COSMICSH3BP2, SYK, TEC, EGFR, P

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs186483354A168V1000Genome
    2rs184362178I235N1000Genome
    3rs117819421V279ICluster,Frequency,1000Genome
    4rs144739934E475KFrequency
    5rs61750003T539ACluster
    6rs146852359H581RCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP00318Uterine CancerTreatment(none vs. transfected with the pOP13 vector that containing E7)The HPV negative cervical cancer cell line, C33A(C33A/mock control cells)The HPV negative cervical cancer cell line(C33A) transfected with the pOP13 vector that containing E7(C33A/E7 transfectants)cell line14997504  



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