ID you entered:  ENSP00000307940

Ensembl protein: ENSP00000307940   

          Protein sequence 
Name: EEF2
Description: eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0827795, hypergeometric test )
                 50 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.000000000269011, hypergeometric test )
                 37 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs81330V137L1PF00009  Head and Neck Cancer21798893   COSMICEEF2
    2cs20762A508V0Skin Cancer21984974   COSMIC
    3cs84326R633H0PF03764  Head and Neck Cancer21798893   COSMICEEF2

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs76914868G52ECluster
    2rs35967493E80KCluster
    3rs145985140G95SCluster,Frequency,1000Genome
    4rs2230560H108QCluster,Frequency,1000Genome,HapMap
    5rs200480185G271SCluster
    6rs201085536I321VCluster
    7rs114174651I354M1000Genome
    8rs76252955V509GCluster
    9rs199771838E510GCluster
    10rs35805642H769QCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP00024Uterine CancerNormal vs. CancerNegative for Intraepithelial Lesions or Malignancy (NILM)High-Grade Squamous Intraepithelial Lesion(HSIL) tissue17902640  
    2EXP00151Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)hepatocellular carcinoma (HCC-S102, HepG2, SK-Hep-1, and Alexander) cell linescholangiocarcinoma (HuCCA-1) cell linescell line20069059  
    3EXP00167Lung CancerCancer vs. Cancerthe M-BE cells(a SV40T-transformed human bronchial epithelial cell line with the phenotypic features of early tumorigenesis at high passage) at P40 passagethe M-BE cells (a SV40T-transformed human bronchial epithelial cell line with the phenotypic features of early tumorigenesis at high passage) at P140 and P200 passagescell line17284061  
    4EXP00233Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)a hormone-receptor-positive-Her2-negative (Non-TNBC, Case B) tumor specimentriple negative breast cancer (TNBC, Case A) tumor specimencell line20596302  
    5EXP000400.34LeukemiaNormal vs. Cancercontrol (CD34+ selected bone marrow cells)Mixed lineage leukemia (MV4-11 cell line)cell line17022645  
    6EXP000410.34LeukemiaNormal vs. Cancercontrol (CD34+ selected bone marrow cells)Mixed lineage leukemia (RS4:11 cell line)cell line17022645  
    7EXP001940.42Gastric CancerTreatment (none vs. Vincristine-resistant)human gastric carcinoma cell line SGC7901Vincristine-resistant human gastric carcinoma cell line SGC7901/VCRcell line18253933  
    8EXP003200.45Gastric CancerNormal vs. Cancerprecancerous, spasmolytic polypeptide EXPressing metaplasia(SPEM)gastric adenocarcinomatissue15761955  
    9EXP003200.5Gastric CancerNormal vs. Cancerprecancerous, spasmolytic polypeptide EXPressing metaplasia(SPEM)gastric adenocarcinomatissue15761955  
    10EXP002220.68Breast CancerMetastasisnoninvasive breast cancer cells (MCF-7) [Total Cell Proteomes]invasive breast cancer cells (MB-MDA-231) [Total Cell Proteomes]cell line20052998  
    11EXP002680.8-11.4Renal CancerNormal vs. Cancernormal renal cortex samples from patientsmalignant RCC tissue samples from patients tissue12923786  
    12EXP002211.1Breast CancerNormal vs. Cancernormal breast cells (MCF-10A) [Total Cell Proteomes]invasive breast cancer cells (MB-MDA-231) [Total Cell Proteomes]cell line20052998  
    13EXP000541.3Oral Premalignant LesionsNormal vs. Cancernormal oral tissues 1oral premalignant lesions (OPLs) tissues 1tissue19072117  
    14EXP000591.3Oral Premalignant LesionsNormal vs. Cancernormal oral tissues 6oral premalignant lesions (OPLs) tissues 6tissue19072117  
    15EXP000581.4Oral Premalignant LesionsNormal vs. Cancernormal oral tissues 5oral premalignant lesions (OPLs) tissues 5tissue19072117  
    16EXP003091.4Gastric CancerTreatment (none vs. drug-resistant)gastric cancer SGC7901 cellsdrug-resistant SGC7901 cells (SGC7901/VCR)cell line20625496  
    17EXP000211.5Prostate CancerTreatment (none vs. bicalutamide treatment)androgen (R1881) on the androgen-responsive prostate cancer LNCaP cell lineanti-androgen (bicalutamide) on the androgen-responsive prostate cancer LNCaP cell linecell line17152098  
    18EXP000551.5Oral Premalignant LesionsNormal vs. Cancernormal oral tissues 2oral premalignant lesions (OPLs) tissues 2tissue19072117  
    19EXP002201.6Breast CancerNormal vs. Cancernormal breast cells (MCF-10A) [Total Cell Proteomes]noninvasive breast cancer cells (MCF-7) [Total Cell Proteomes]cell line20052998  
    20EXP003411.6Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)GEM sensitive human pancreatic adenocarcinoma cell line KLM1GEM-resistant human pancreatic adenocarcinoma cell line KLM1-Rcell line20944110  
    21EXP002921.7Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)Paclitaxel Sensitive A2780 Epithelial Ovarian Cancer Cell LinePaclitaxel Resistant A2780TC1 Epithelial Ovarian Cancer Cell Linecell line19714814  
    22EXP000211.9Prostate CancerTreatment (none vs. bicalutamide treatment)androgen (R1881) on the androgen-responsive prostate cancer LNCaP cell lineanti-androgen (bicalutamide) on the androgen-responsive prostate cancer LNCaP cell linecell line17152098  
    23EXP002922.1Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)Paclitaxel Sensitive A2780 Epithelial Ovarian Cancer Cell LinePaclitaxel Resistant A2780TC1 Epithelial Ovarian Cancer Cell Linecell line19714814  
    24EXP001002.2Breast CancerTreatment (none vs. 17b-Estradiol treatment)MCF-7 human breast cancer cells"MCF-7 human with 17b-Estradiol treatment breast cancer cells"cell line18491314  
    25EXP000212.4Prostate CancerTreatment (none vs. bicalutamide treatment)androgen (R1881) on the androgen-responsive prostate cancer LNCaP cell lineanti-androgen (bicalutamide) on the androgen-responsive prostate cancer LNCaP cell linecell line17152098  
    26EXP000212.7Prostate CancerTreatment (none vs. bicalutamide treatment)androgen (R1881) on the androgen-responsive prostate cancer LNCaP cell lineanti-androgen (bicalutamide) on the androgen-responsive prostate cancer LNCaP cell linecell line17152098  
    27EXP001022.9hepatitis B virusNormal vs. Cancersurrounding nontumorous liver tissueshepatitis B surface antigen-positive (B-type HCC)tissue14654528  
    28EXP001032.9hepatitis C virusNormal vs. Cancersurrounding nontumorous liver tissuesanti-HCV-positive (C-type HCC)tissue14654528  
    29EXP001042.9Hepatocellular CarcinomaNormal vs. Cancersurrounding nontumorous liver tissueshepatitis B surface antigen-negative and anti-HCV-negativetissue14654528  
    30EXP003413.1Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)GEM sensitive human pancreatic adenocarcinoma cell line KLM1GEM-resistant human pancreatic adenocarcinoma cell line KLM1-Rcell line20944110  
    31EXP002166.2Breast CancerNormal vs. Cancernormal interstitial fluids (NIF) from prospective breast cancer patientstumour interstitial fluids (TIF) from prospective breast cancer patientstissue20005186  



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