ID you entered:  ENSP00000337332

Ensembl protein: ENSP00000337332   

          Protein sequence 
Name: SIRT6
Description: sirtuin 6 [Source:HGNC Symbol;Acc:HGNC:14934]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.199028, hypergeometric test )
                 10 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs3304G8E-2Melanoma COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs352493S46NCluster,Frequency,1000Genome,HapMap
    2rs138839184A58TCluster
    3rs199849196F86SCluster
    4rs200742459R90WCluster
    5rs200364417V149ICluster
    6rs114189165R150Q1000Genome
    7rs149957544E202KFrequency
    8rs191314480G223R1000Genome
    9rs200395703N224TCluster
    10rs147362434R235HCluster
    11rs74317014A275TCluster,Frequency,1000Genome
    12rs183444295A313S1000Genome
    13rs192661013H342D1000Genome
    14rs201974715K346RCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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