ID you entered:  ENSP00000349932

Ensembl protein: ENSP00000349932   

          Protein sequence 
Name: PTPRS
Description: protein tyrosine phosphatase, receptor type, S [Source:HGNC Symbol;Acc:HGNC:9681]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.14734, hypergeometric test )
                 19 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.196994, hypergeometric test )
                 5 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs19198P141S-1PF07679  Melanoma19074898   COSMIC
    2cs79452A157V0PF07679  Melanoma19074898   COSMIC
    3cs17246N181K0PF07679  Melanoma19074898   COSMIC
    4cs98208R188*-4PF07679  Ovarian Cancer21720365   COSMIC
    5cs37707V224M1PF07679  Intestines Cancer17932254   COSMIC
    6cs76313P287L-3PF07679  Melanoma19074898   COSMIC
    7cs67297E415K1Head and Neck Cancer21798893   COSMIC
    8cs37526P511L-3PF00041  Melanoma19074898   COSMIC
    9cs41971T996A0PF00041  Ovarian Cancer21720365   COSMIC
    10cs2351T996M-1PF00041  Colorectal Cancer16959974   HPI
    11cs70545D1389N1Melanoma19074898   COSMIC
    12cs51349P1467S-1PF00102  Central Nervous System Neoplasms18772396   COSMIC
    13cs98326E1511K1PF00102  Melanoma19074898   COSMIC
    14cs13261G1514V-3PF00102  Ovarian Cancer21720365   COSMIC
    15cs54823T1553K-1PF00102  Skin Cancer21984974   COSMIC
    16cs26760P1809S-1PF00102  Melanoma19074898   COSMIC
    17cs80441P1920T-1PF00102  Skin Cancer21984974   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs61729776C27YCluster,Frequency,1000Genome
    2rs115231439K40R1000Genome
    3rs146675930T80MCluster,Frequency
    4rs114080870V113ACluster,Frequency,1000Genome
    5rs139336866N136SCluster
    6rs79388082S361FCluster
    7rs79960932S361TCluster
    8rs115982731T385I1000Genome
    9rs73545312V462ICluster,1000Genome
    10rs144686472E495KCluster,1000Genome
    11rs145504993P548LFrequency
    12rs185326821P575L1000Genome
    13rs138765579A591TCluster
    14rs141070507R835C1000Genome
    15rs199604489R851LCluster
    16rs115276698E853A1000Genome
    17rs151114416R872C1000Genome
    18rs200860780A907VCluster
    19rs61729778R929CFrequency,1000Genome
    20rs201357930A978TCluster
    21rs201357930A987TCluster
    22rs2230610A991V1000Genome
    23rs201357930A991TCluster
    24rs3202678F1097LHapMap
    25rs201447856T1112MCluster
    26rs140049694G1136SFrequency
    27rs115469963R1190HCluster,1000Genome
    28rs115469963R1194HCluster,1000Genome
    29rs142918634R1206QCluster,Frequency,1000Genome
    30rs114904537H1221N1000Genome
    31rs202091186R1241HCluster
    32rs116545788V1249MCluster,Frequency,1000Genome
    33rs114166264R1384QCluster,Frequency,1000Genome
    34rs114545401A1427TCluster,1000Genome
    35rs190342971P1437L1000Genome
    36rs192807174V1452M1000Genome
    37rs4807697C1457RCluster,Frequency,1000Genome,HapMap
    38rs189135288A1460T1000Genome
    39rs116660613P1467LCluster,1000Genome
    40rs147152459T1486MCluster
    41rs116515629V1488I1000Genome
    42rs147152459T1510MCluster
    43rs116099658G1514SCluster,1000Genome
    44rs182037655T1553M1000Genome
    45rs148739536R1595QFrequency
    46rs142364974R1595WCluster,Frequency
    47rs148739536R1608QFrequency
    48rs142364974R1608WCluster,Frequency
    49rs61729772G1650CFrequency
    50rs61729772G1674CFrequency
    51rs1064301N1701KHapMap
    52rs1064301N1705KHapMap
    53rs116345982V1776MCluster,1000Genome
    54rs148478353S1852LCluster,Frequency,1000Genome
    55rs142977438V1889ICluster,Frequency,1000Genome
    56rs115470613T1911M1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP000232Prostate CancerTreatment (androgen-starved vs. androgen-stimulated)prostate tumor-derived LNCaP cell line grown in a low protein-defined media under androgen-starved (A-)prostate tumor-derived LNCaP cell line grown in a low protein-defined media under androgen-stimulated (A+)cell line14729644  



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