ID you entered:  ENSP00000353826

Ensembl protein: ENSP00000353826   

          Protein sequence 
Name: LONP1
Description: lon peptidase 1, mitochondrial [Source:HGNC Symbol;Acc:HGNC:9479]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0432007, hypergeometric test )
                 18 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.067519, hypergeometric test )
                 7 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs18353Y599*-4PF00004  PF07724  PF07728  Head and Neck Cancer21798893   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs34413649E87DCluster,Frequency,1000Genome
    2rs201187879R158HCluster
    3rs148374055A160TFrequency
    4rs139555567S176LCluster,Frequency,1000Genome
    5rs147052599T188MCluster,1000Genome
    6rs199803800R205HCluster
    7rs201029843Q219LCluster
    8rs80050321A229VCluster,Frequency,1000Genome
    9rs11085147R241QCluster,Frequency,1000Genome,HapMap
    10rs11551017K244QCluster,Frequency
    11rs149169865D248NCluster,Frequency,1000Genome
    12rs188155859P255L1000Genome
    13rs116591583A256VCluster,Frequency,1000Genome
    14rs139791767T263ICluster,Frequency
    15rs11551014N277DCluster
    16rs139554429V437ICluster,Frequency,1000Genome
    17rs148214998V497ICluster,Frequency,1000Genome
    18rs143983421V507ICluster
    19rs115968490R538HFrequency
    20rs199574163S604LCluster
    21rs145519500A606VFrequency
    22rs147307965V626MFrequency
    23rs34402166V641ICluster,1000Genome
    24rs141420305T644AFrequency
    25rs149596661E647KCluster
    26rs186834921R650Q1000Genome
    27rs144822855V662GFrequency
    28rs138134205R672HCluster
    29rs151025018V675LCluster,Frequency,1000Genome
    30rs200466559F824CCluster
    31rs35804229A829TCluster,Frequency,1000Genome
    32rs147591431A848TCluster,Frequency
    33rs112807920R904HCluster,Frequency
    34rs61737436I910VCluster
    35rs1062373V911ICluster,Frequency,1000Genome
    36rs138631909D944N1000Genome
    37rs142068825A946TFrequency
    38rs139759295A952VFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP00284Testicular CancerNormal vs. CancerHuman embryonic stem cells (hESC) line HUES-7 Human embryonal carcinoma cells (hECCs) line NT2/D1cell line18489135  
    2EXP000151.6Gastric CancerMetastasisthe noninvasive gastric cancer SC-M1 cellthe metastatic gastric cancer TMC-1 cellscell line17022644  
    3EXP001861.6Gastric CancerMetastasisthe noninvasive gastric cancer SC-M1 cell(a well-established human gastric carcinoma cell line, originally cultured from a poorly differentiated adenocarcinoma that invaded through the stomach wall but showed no metastasis to lymph nodes or adjacent organs)the metastatic gastric cancer TMC-1 cells(derived from the lymph node of an individual with a moderately differentiated adenocarcinoma of the stomach and exhibited highly tumorigenic features)cell line17022644  



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