ID you entered:  ENSP00000357484

Ensembl protein: ENSP00000357484   

          Protein sequence 
Name: GOPC
Description: golgi-associated PDZ and coiled-coil motif containing [Source:HGNC Symbol;Acc:HGNC:17643]
Location:
            chr6 q22.1
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0711875, hypergeometric test )
                 22 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs14962G5D-1Lymphocytic Leukemia23856246   COSMIC
    2cs49592S86F-2Uterine Cancer COSMIC
    3cs81700Q97E2Lung Cancer23033341   COSMIC
    4cs66079L98F0Breast Cancer COSMIC
    5cs75099K117N0Renal Cancer COSMIC
    6cs75099K117N0Ovarian Cancer20826764   COSMIC
    7cs10917A141V0Skin Cancer(Melanoma) COSMIC
    8cs91007T145I-1Ovarian Cancer COSMIC
    9cs91739P153L-3Skin Cancer(Melanoma) COSMIC
    10cs64798E163Q2Lung Cancer COSMIC
    11cs11691A164T0Lymphocytic Leukemia23292937   COSMIC
    12cs74253R190C-3Intestines Cancer COSMIC
    13cs70813Y201N-2Skin Cancer(Melanoma) COSMIC
    14cs58289A203V0Intestines Cancer22810696   COSMIC
    15cs90002R226Q1Gastric Cancer COSMIC
    16cs78532M228V1Lung Cancer22941188   COSMIC
    17cs62685M228I1Breast Cancer COSMIC
    18cs63621R254Q1Intestines Cancer COSMIC
    19cs26213C256F-2Lung Cancer23033341   COSMIC
    20cs15434G258V-3Lymphocytic Leukemia23292937   COSMIC
    21cs67418G271C-3Gastric Cancer COSMIC
    22cs96897D273E2Liver Cancer COSMIC
    23cs52571D273Y-3Central Nervous System Neoplasms COSMIC
    24cs80149P285T-1Breast Cancer COSMIC
    25cs26360I315T-1PF00595  Liver Cancer COSMIC
    26cs97734D325N1PF00595  Esophageal Cancer22877736   COSMIC
    27cs11455A338V0PF00595  Pancreatic Cancer COSMIC
    28cs65367N343T0PF00595  Lung Cancer22941188   COSMIC
    29cs87778K348N0PF00595  Intestines Cancer COSMIC
    30cs53110Q358H0PF00595  Intestines Cancer COSMIC
    31cs55693G420V-3Lymphocytic Leukemia23292937   COSMICrs79478098
    32cs30534F421C-2Intestines Cancer COSMIC
    33cs72026G446D-1Gastric Cancer COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs116169595E35Q1000Genome
    2rs138303594G53EFrequency
    3rs147033047L123VFrequency
    4rs114052904Q125RCluster,Frequency,1000Genome
    5rs41311406G225RCluster,1000Genome
    6rs149195394K278RFrequency
    7rs200868852V283ICluster
    8rs190842667P320L1000Genome
    9rs116098352V332I1000Genome
    10rs187297771G341R1000Genome
    11rs115242892V381I1000Genome
    12rs114794575R392HCluster,Frequency,1000Genome
    13rs79478098G420VCluster
    14rs201340669L453PCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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