CanProVar 2.0:Human Cancer Proteome Variation Database

ID you entered: ENSP00000381216

Ensembl protein: ENSP00000381216

Protein sequence

Name: KHSRP

Description: KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316]

Location:

chr19 p13.3

Gene Ontology:

Biological process

Molecular function

Cellular localization

Interactions:

Interaction partner with cancer_related variations : ( pvalue=0.133331, hypergeometric test )

Interaction partner with cancer related differentially expressed proteins : ( pvalue=0.127227, hypergeometric test )

Cancer-related variations in CanProVar:

NO.	csID	variation	change conservation⁺	Domain	cancer name	PubMed	data source⁺⁺	validated dbSNP*	interface
1	cs8233	P520L	-3		Melanoma		COSMIC

⁺Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
⁺⁺Data sources: HPI, COSMIC, OMIM, TCGA, BIOMART, Greenman2007, Sjoblom2006, Ding2008
*Cross-reference databases: dbSNP
Interface information was collected from Wang 2012

Non-cancer specific variations derived from database dbSNP:

NO.	dbSNP_ID	variation	validated
1	rs61751242	A92S	Cluster,Frequency,1000Genome
2	rs200857160	F103L	1000Genome
3	rs201259560	K109R	1000Genome
4	rs202063550	G127R	1000Genome
5	rs199917639	S132F	1000Genome

Cancer-related differential expression proteins derived from database dbDEPC:

NO.	dbDEPC_ID	ratio	cancer name	design	sample_control	sample_case	sample	pubmed
1	EXP00276	1.3	Sarcoma	Cancer vs. Cancer (subtype)	The internal control consisted of a mixture of all the protein samples. 6 clear cell sarcomas, 10 myxoid liposarcomas,9 gastrointestinal stromal tumors (GIST),5 malignant peripheral nerve sheath tumors (MPNST),12 synovial sarcomas, 28 MFH (10 myxoid and 18 pleomorphic),and 10 leiomyosarcomas (7 conventional and 3 pleomorphic)	28 Malignat fibrous histiocytoma(MFH) (10 myxoid and 18 pleomorphic)	tissue	16807943
2	EXP00341	2.1	Pancreatic Cancer	Treatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)	GEM sensitive human pancreatic adenocarcinoma cell line KLM1	GEM-resistant human pancreatic adenocarcinoma cell line KLM1-R	cell line	20944110
3	EXP00135	2.3	hepatitis B virus	Normal vs. Cancer	the adjacent nontumour (normal) tissues	poorly differentiated liver tumour tissues	tissue	19003864

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