ID you entered:  ENSP00000381657

Ensembl protein: ENSP00000381657   

          Protein sequence 
Name: DOT1L
Description: DOT1-like histone H3K79 methyltransferase [Source:HGNC Symbol;Acc:HGNC:24948]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.169481, hypergeometric test )
                 19 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs57438A353T0Pancreatic Cancer21930502  21930507   BIOMART

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs138206172A353G1000Genome
    2rs201929424A478VCluster
    3rs138541851A687T1000Genome
    4rs880525L726MCluster,Frequency
    5rs201013553A796VCluster
    6rs188376638V1046L1000Genome
    7rs144165419A1053T1000Genome
    8rs201872028A1071TCluster
    9rs146482120G1080V1000Genome
    10rs61741267R1086CCluster
    11rs201546034G1309DCluster
    12rs113164803L1379MCluster,Frequency,1000Genome
    13rs3815308G1386SCluster,1000Genome
    14rs2302061V1418LCluster,Frequency,1000Genome
    15rs113842228G1443CCluster,Frequency,1000Genome
    16rs78539344G1453SCluster,1000Genome
    17rs150855728A1475T1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



    [ continue search ]



    Dr. Jing Li's Group

    ©2015 Menghuan Zhang, Jing Li